Sunday, May 3, 2009
Modi Mundipharma Forms JV with Omega Pharma
Source: Economic Times
Monday, April 27, 2009
Piramal plans to buy 2-3 firms in U.S., Europe
Piramal Healthcare Ltd is eyeing acquisitions in the U.S. and Europe, and expects growth in business during the current fiscal year to remain same as that in FY09, a senior official said on Wednesday. "We expect to buy 2-3 companies in advanced markets like the U.S. and Europe," Swati Piramal, director, Piramal Healthcare told reporters. "The company expects the same level of growth as witnessed in the last fiscal," she said, adding the firm plans to add 300-400 professionals in the super-speciality marketing division. She ruled out any proposal to sell stake in Piramal Healthcare or Piramal Life Sciences Ltd.
Source: Reuters
Elder Health Care eyeing brand acquisitions
Merieux Alliance Part Selling from Shantha Biotech
French healthcare company Merieux Alliance, which holds a 78.85 per cent stake in Hyderabad-based vaccine manufacturer and biopharmaceutical firm Shantha Biotechnics, might dilute some of its stake, according to Shantha founder and MD KI Vara Prasad Reddy. The company has, however, assured to remain a majority stakeholder and hold at least 51 per cent to ensure that the new partner did not bring a drastic change in the line of operations. The dilution of stake is to bring in new technology, new products or enter new markets or a combination of these. Reddy holds a 14.1 per cent stake in Shantha. The French company picked up a majority stake (60 per cent) in Shantha Biotechnics in November 2006 from Oman-based financial firms to strengthen its India presence. On reports that Shantha was a target for an acquisition, he said the company was attractive with proven capabilities in vaccine development and market penetration and, therefore, many companies including one from Hyderabad were eyeing to acquire it. "I declined to sell my stake in the company so some of them are approaching Merieux for dilution of its stake,'' Reddy said, adding the company, which is not seeing any drastic upward or downward surges, had been getting acquisition proposals from various companies since the late 90s.
Interacting with the media here on Friday on the sidelines of announcing the launch of Shanchol, an oral cholera vaccine, he said the company would continue to work on low-cost vaccines. Shanchol would be priced at about Rs 300 per dose of 1.5 ml and two doses were needed to give protection against cholera for about four years. The commercial launch would be in June or July.
The company has invested about Rs 5 crore over three years in developing Shanchol in collaboration with the International Vaccine Institute, Seoul. It received funding from the Bill and Melinda Gates Foundation for the project. Currently, the Hyderabad facility has a capacity to manufacture 5 million doses, which would be ramped up to 25 million doses in about six months.
Source: Business Standard
Friday, April 24, 2009
Inbound merger and acquisitions set to increase: Assocham
Strong financials of domestic companies and robust demand in sectors like telecom, pharma and capital goods will kickstart inbound merger and acquisition (M&A) activities in India in the next six to nine months, an industry lobby report said Thursday. The report by the Associated Chambers of Commerce and Industry (Assocham) said: 'Inbound M&As, which had witnessed a steep fall of 85 percent due to the global financial crisis, and consolidation deals are expected to show signs of revival by October-December period 2009.' Assocham president Sajjan Jindal said in the report: 'Indian companies could attract greater number of inbound M&A deals as the equity valuations of certain sectors like telecom, pharma, and capital goods offer lucrative strategic option to bigger foreign companies.' In January-March 2009, the inbound M&A deals, which had the maximum share in total M&A deal size during October-December 2008, contracted by a whopping 85.28 percent. The outbound M&A deals shrunk 48.62 percent as the number of deals declined from 28 in October-December 2008 to 16 in January-March 2009, the report said. The aggregate M&A deals size plunged more than 70 percent in the first quarter of 2009. The number of deals also declined from 58 to 45 during the period. The Study also found that if it was the telecom sector that attracted the maximum share in the M&A deals in the last quarter of 2008, the pharmaceutical and IT sectors dominated the corporate M&A activities in the first three months of 2009.
Source: Reuters
Wednesday, April 22, 2009
Piramal Health eyes acquisitions in US, Europe
Piramal Healthcare Ltd is looking for acquisitions in the US and Europe, a senior official said, adding that business should grow during the current fiscal year at about the same pace it did in 2008-09.
Piramal recently acquired US-based inhalation anaesthetics maker Minrad International Inc to boost its presence in the global critical care business and director Swati Piramal said they were looking for more.
“We expect to buy 2-3 companies in advanced markets like the US and Europe,” she told reporters on the sidelines of a conference.
Piramal Healthcare reports results for its fourth quarter ended March on Friday.
Piramal Healthcare and a related firm Piramal Life Sciences Ltd would together invest about Rs1 billion during the 12 months to March 2010, mostly on new drug development and research, she said.
The company is in the process of phase II trials of a cancer drug and expect to get approvals in the US, Australian and Indian market this year, Swati Piramal said, adding 14 new drugs were in the pipeline.
The firm plans to add 300-400 professionals in the super-speciality marketing division, she added, ruling out any plan to sell stake in Piramal Healthcare or Piramal Life Sciences Ltd.
Piramal Healthcare employs about 7,000 employees in total, she said.
Shares in Piramal Healthcare closed 0.1% higher at Rs211.05 in a Mumbai market that ended 0.74% down, while Piramal Life Sciences shares fell 1.9% to Rs48 rupees.
Source: Mint
Tuesday, April 21, 2009
Indian Angel Network Invests in Online Library and A Mumbai Based CRO
IAN members Ajay Garg and Shankar Maruwada, among others, have invested in Kwench and have also taken up seats on the company board. Ajay Garg is the founder of Equirus Capital and was an investment banker with DSP Merrill Lynch. Muruwada, is the founder of Marketics, a marketing analytics services provider.
Kwench is conceived and founded by four Indian Institute of Management (IIM) Ahmedabad alumni- Sunder Nookala, Mitesh Damania, Prashant Koshy and Krishnan Madhabushi. Kwench works on a model that allows corporates to order books online, which is followed by the physical delivery of the ordered books to the employees’ offices or homes.
Kwench’s clientelle include Wipro, WNS. Kwench’s expansion plans include multi city operations and building a multi product-service platform.
According to Mitesh Damania, Kwench founder, “The IAN investment is smart money for Kwench. It is an investment which comes with a wealth of experience, huge potential for building our client base and most importantly, brings valuable guidance as we build this nascent venture, into what we hope, to be a trendsetter company.”
Karmic Lifesciences, on the other hand, is a Mumbai based CRO (clinical research organisation) focused on oncology. It was founded in 2006. Karmic provides concept to clinic services for new drugs as well as generics development and its services include Regulatory Strategy/Submissions, pre-clinical support, clinical trial management (Phase I to IV), clinical data management, bio-statistics and pharmacovigilance services.
Karmic is also partnering with early stage R&D innovators to co-develop and create joint IP on promising new molecules in various stages of development and take them to market.
Source: VCCIRCLE
Friday, April 10, 2009
Natco, Lupin in alliance to market tablets for kidney ailments
“Natco Pharma has joined hands with Lupin to jointly commercialise generic equivalents of Lanthanum Carbonate tablets,” Natco said in a filing to the Bombay Stock Exchange.
Lanthanum Carbonate tablets, invented by Shrine Plc, are sold under the brand name of Fosrenol. Natco had filed an abbreviated new drug application (ANDA) before the US drug regulator (Food and Drug Administration) to market the generic versions of Fosrenol in three different strengths. In response to the application, Shrine had filed two law suits against Natco alleging patent infringement for the drug, which Natco is defending. As of December 2008, global sales of Fosrenol amounted to $108 million. The two Indian drug makers (Natco and Lupin) believe that they are among the first to file for this product, which may lead to 180 days’ exclusivity for its marketing in the US. “This alliance brings together a strong philosophy of working together to maximise opportunities in an increasingly competitive generic business,” Natco Pharma director and chief operating officer Rajeev Nannapaneni said. Natco closed at Rs59.35, up 14.80%, while Lupin settled the day at Rs646.75, down 1.03% on BSE.
Monday, April 6, 2009
Sanofi, Piramal proposed merger deal falls through
Wednesday, April 1, 2009
Novavax, Cadila form JV for developing vaccines
The joint venture will develop and commercialise Novavax's VLP-based vaccine and Cadila's therapeutic vaccine candidates against cancer as well as its adjuvants, biogeneric and biological diagnostic products for the Indian territory, Navavax said in filing to Security Exchange Commission (SEC). Novavax would provide the technology and Cadila would invest $8 million (Rs 40 crore) over three years to support the joint venture operations, it added.
In the proposed joint venture, Cadila would have 80 per cent stake while remaining 20 per cent will held by Novavax, company said. Novavax will also have the right to negotiate license arrangements of certain vaccines developed by the joint venture for commercialising it outside the India. As part of the agreement which both companies signed on March 31, 2009, a wholly-owned subsidiary of Cadila will purchase 12.5 million shares of Novavax's common stock at the market price of $0.88 per share, for an aggregate of $11 million (Rs 55 crore). Cadila Managing Director Rajiv Modi will join the Novavax Board of Directors immediately.
Lilly in CV pact with India's Zydus
Eli Lilly has signed up another drug development partner in India, having inked a cardiovascular research pact with Zydus Cadila.Under the terms of the six-year deal, Zydus will be responsible for the drug discovery and development process up to Phase II and Lilly will have an option to license any promising molecules that emerge from the colloboration. Cashwise, the Ahmedabad-headquartered company could bank up to $300 million in milestone payments plus royalties.William Chin, vice president of discovery research and clinical investigation at Lilly, said that Zydus has “unique capabilities to discover and advance these candidates” and “we are excited to explore this innovative drug discovery and development model with them". Lilly already has partnerships with other Indian drugmakers. Last October it set up a 50:50 joint venture in India with the country’s Jubilant Organosys to provide drug development services to the companies' partnered molecules in the oncology, metabolic disorders, cardiovascular and diabetes fields. The US major also has alliances in place with Nicholas Piramal and Suven Life Sciences.
Schizophrenia drug flops in Phase II
Less good news for Lilly came after the firm presented “inconclusive” Phase II results from a study of its investigational schizophrenia treatment LY2140023. The data on the drug, a mGlu2/3 receptor agonist, was presented at the International Congress on Schizophrenia Research in San Diego, USA.Lilly said that in the Study HBBI, neither LY2140023, nor the comparator drug, the firm’s blockbuster Zyprexa (olanzapine), separated from placebo. In fact, the company observed “a greater-than-expected placebo response, which was approximately double that historically seen in schizophrenia clinical trials”.The news is a big blow to Lilly, given the excitement surrounding LY2140023. It has been touted as a new class of schizophrenia drug as it targets glutamate-mediated neurotransmission. All current antipsychotics act on dopamine receptors, and that mode of action is thought to be responsible for unpleasant extrapyramidal side effects such as involuntary movement.Lilly is not giving up on the compound and said it plans an additional Phase II trial, Study HBBM, which if positive, would validate earlier proof-of-concept results. Steven Paul, president at Lilly Research Laboratories, stated that the firm remains optimistic that “the novel mechanism of compounds with the ability to reduce glutamate hyperactivity…will someday represent the next generation of breakthrough treatments for schizophrenia”.
Lilly to hit the acquisition trail?
However analysts are concerned about the failure of this trial and fear that Lilly's pipeline is not strong enough to compensate for drugs that will be going off-patent in the next few years, most importantly Zyprexa. An acquisition could provide a solution and chief executive John Lechleiter has told the Wall Street Journal that deals in the region of $15 billion could appeal. In an earlier interview, with the Financial Times, Mr Lechleiter said the company is not interested in a mega-merger, and he ruled out a linked-up with Bristol-Myers Squibb. “I think we are seeing deals that are really driven more by weakness than what I would describe as strong strategic combinations,” he told the FT. “That will improve short-term problems but fail to answer the long-term question of research productivity.
Tuesday, March 31, 2009
Canada’s SciMed close to signing deal with Mumbai firm
“We are still working on the device and have confirmed an Indian distributor. I cannot disclose the name (of the company) now because we are still to sign a formal agreement, in the next few weeks,” said Rajan Gupta, president, SciMed Technologies.
Test kit: A scientist at SciMed Technologies tests the lab-on-chip devices at its research and development facility in Edmonton, Canada. Jacob P. Koshy / MintThe so-called lab-on-chip devices, rectangular and transparent, are not bigger than your thumb. Intricate channels etched on this chip are as thin as strands of hair and separate liquids into their biological basics such as proteins.
These chips are then plugged into special card readers that relay data to a computer, in which custom-designed software can detect the presence of desired molecules.
SciMed, which is still perfecting its proprietary Nutrachip, as they are called, expects to launch the devices in the country by 2010, said Gupta. He didn’t disclose details of the likely pact with the Indian company.
Currently, laboratories use the ELISA (enzyme linked immunosorbent assay) and HPLC (high-performance liquid chromatography) techniques for testing blood and food samples, using large and expensive devices that can take from several hours to weeks depending on the protein that needs to be analysed.
Several such tests require significant quantities of various chemicals. SciMed’s chips, according to Gupta, won’t need more than a 1,000th of a litre of a sample and also use fewer chemicals.
However, lab-on-chips are still largely in research phase. “Several universities across the world are trying to make effective chips at reasonable costs. As of today, no lab in India uses diagnostic devices of this sort,” said Chandrashekhar Nair, a director at Bangalore-based Bigtec Labs, a start-up that has developed a hand-held device for rapidly detecting Hepatitis B. Nair said Bigtec Labs is in talks with SciMed in a separate deal for another class of diagnostic devices.
According to Nair, high costs for designing such chips and the absence of dedicated manufacturing facilities are barriers to commercial production.
“Just as manufacturing silicon chips needs a well-developed physical infrastructure, even lab-on-chips require good design facilities. Moreover, scientists are still working on practical difficulties, such as having to use a separate chip for each experiment, that make them expensive to
Mediation to resolve Sun-Taro dispute fails
Fortis likely to buy 74% of Wockhardt hospitals for Rs750 crores
Monday, March 30, 2009
Cadila signs drug development deal with Eli Lily
Saturday, March 28, 2009
Lupin buys stake in Multicare Pharma - Philippines firm
Earlier this month, Lupin's president-finance and planning, S Ramesh, had said the company continues to scout for acquisitions in Asia, eastern Europe, the Gulf region and Latin America.
Last year, Lupin's acquisitions included stakes in South Africa's Pharma Dynamics, Germany's Hormosan Pharma and Australia's Generic Health. (Reporting by Bharghavi Nagaraju; Editing by Ramya Venugopal)
Thursday, March 26, 2009
Novartis Offers To Buy 39% More Of India Unit At INR351/Share
Wednesday, March 25, 2009
Reliance shrinks its big pharma plan
The plan was announced a year earlier, and the new company floated, but the group’s flagship company, Reliance Industries Ltd (RIL), is now grappling with other priorities -- sliding oil prices, shrinking refining margins and a battle with the Anil Ambani group over supply of gas.
The plan was to build an integrated pharma company in two to three years, on the lines of the large domestic majors such as Ranbaxy’s or Dr Reddy’s Laboratories. Instead, the plan has been modified to being a start-up bulk drug manufacturing company, that will launch six bulk drugs or active pharmaceutical ingredients (APIs) by next year.
“We have put on hold our plan for large-scale formulation development and will re-organise the project to start with about 10 bulk drugs. We will go forward slowly, by consolidating our entry into bulk drugs,” K V Subramaniam, president of Reliance Life Sciences (RLSL), told Business Standard.
Privately-held RLSL is an umbrella company -- Reliance Pharma is its subsidiary -- that co-ordinates the healthcare businesses of the group. Seven years old, it is into biotech drug research, stem cell therapies, biodiesel production, cord blood banking and clinical research.
Reliance Life Sciences has also suspended its plan to invest Rs 1,000 crore in a special economic zone at Jamnagar in Gujarat for setting up world-class multiple drug manufacturing facilities. Instead, it has started a pilot facility to make pharmaceutical bulk drugs at its Navi Mumbai headquarters.
Subramaniam said Reliance Pharmaceuticals would focus on high-value bulk drugs, mainly in the field of cancer, peptides, steroids and hormones. Six products in oncology and steroids are likely to be ready for commercialisation by next year.
Earlier, the plan was to have Reliance Pharma launch numerous formulations and APIs in various global markets in two-three years to take on seasoned Indian generic drug-makers such as Ranbaxy, Dr Reddy's Lab and Sun Pharma, as well as overseas players such as Israel-based Teva Pharmaceuticals.
Monday, March 23, 2009
SBW plans global buy
Sunday, March 22, 2009
Sun Pharmaceutical extends offer to buy Taro stake
"The mediation process with Levitt and Moros families, initiated at the behest of Supreme Court recommendation, is ongoing," said a Sun Pharma official, declining to disclose further details.
Independent sources said the negotiations were mainly on revised price at which Sun Pharma could buy out the shares of the promoters. Sun Pharma is attempting to acquire the remaining 64 per cent stake of promoters Levitt and Moros families and other shareholders in Taro.
Taro Pharmaceutical, one of the largest generic companies operating in the US market, had demanded a 58 per cent premium, or $15 per share, in cash to effect a merger with Sun Pharmaceutical Industries. However, Sun Pharma rejected the offer citing it was beyond the worth of Taro, which did not disclose audited results for three years and restated accounts.
Sun's offer was a maximum of $9.50 per share with two options. Thus the earlier rounds of discussions had failed and both parties demanded the Court to give a verdict. However, the court directed Sun Pharma and Taro to re-negotiate through a mediator. Sun's tender offer is at a price of $7.5 per share.
Sun Pharma managing director Dilip Shanghvi and Taro chairman Barrie Levitt met in Israel last month to discuss a compromise in the presence of advocate Ram Caspi, who is mediating the discussion, Israeli newspapers had reported a few weeks ago.
The tender offer, which was triggered by Sun Pharma in June, last year following the failure of a merger agreement, was to expire on March 20. Sun Pharma said the offer would expire on April 3, unless further extended or earlier terminated. The offer was extended to comply with an order issued by the Supreme Court of Israel temporarily prohibiting the closing of the offer until the Supreme Court issues a decision on the appeal. Taro and its directors had challenged the applicability of the special tender offer rules under the Israeli Companies Law to the offer.
The Israeli company backed out from a $454 million merger deal signed in May 2007, citing that the fortunes of the company turned around since the merger plan. Following this, Sun Pharma sued Taro in the Supreme Court of New York court for breaching the agreement, while Taro challenged the validity of the tender offer in Israel courts.